Clokeran is a medication used to treat several kinds of cancer and other conditions including Hodgkin’s disease (a type of lymphoma), malignant lymphoma (including lymphosarcoma), clasmocytoma, chronic lymphocytic leukemia, giant follicular lymphoma, hairy cell leukemia (a sub-type of chronic lymphoid leukemia), myeloma, ovarian cancer, breast cancer, Waldenstr?m macroglobulinemia (lymphoplasmacytic lymphoma), Letterer-Siwe disease (genetically stipulated proliferation of histiocytes), chorionepithelioma of the uterus, glomerular nephritis, Beh?et disease (a form of vasculitis), dermatomyositis, rheumatoid arthritis, sarcoidosis, uveitis, nephrotic syndrome. Clokeran’s active substance is chlorambucil, a bifunctional alkylating agent.
Take exactly as prescribed by your doctor. Follow all instructions. The recommended initial dosage for short course of treatment is 0.1 to 0.2 mg/kg body weight (4-10 mg for an average patient) taken daily during 3-6 weeks. The daily dose may be taken as a single dose. In case of the sudden fall in the white blood count or bad tolerance by the patient the dosage should be carefully adjusted. Supporting course of treatment is administered individually.
Warning & Precautions
Hepatic or renal dysfunction. Perform blood counts on a regular basis. Bone marrow suppression and Seizure disorder. Patient who has had myelosuppressive drugs, radiation therapy or has a depressed baseline leukocyte/platelet count within the past 4 week. Enhanced incidence of acute leukaemias and other alternative malignancies.
Side Effects of Clokeran
The most common side effects of Clokeran are nausea, vomiting, changes in menstrual period. Contact your doctor immediately if you have following adverse reactions: painful or difficult urination, fever, chills, black, tarry or bloody stools, easy bruising or bleeding, blood in urine, swollen extremities, sores in mouth or on lips, small red spots on the skin, jaundice, cough, lower back or side pain, joint pain, abdominal pain, confusion, hallucinations, muscle twitching, agitation, trouble walking, weakness, paralysis.
Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not use after expiration term.
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